EOAI3402143 是一种去泛素化酶抑制剂，以剂量依赖性抑制 Usp9x/Usp24和Usp5，增加肿瘤细胞凋亡。

EOAI3402143 inhibits Usp9x and Usp24 activity, increases tumor cell apoptosis. EOAI3402143 phenocopies the FAS induction and apoptotic sensitization of Usp5 knockdown and fully blocks melanoma tumor growth.

EOAI3402143 dose-dependently inhibited Usp9x and Usp24 activity, increased tumor cell apoptosis, and fully blocked or regressed myeloma tumors in mice[2]. Usp9x inhibition by EOAI3402143 treatment reduced 3D colony formation in PANC1 and PDX cell lines, induced rapid apoptosis in MIAPACA2 cells, and associated with reduced Mcl-1 and ITCH protein levels[2].

EOAI3402143 dose-dependently inhibited Usp9x and Usp24 activity, increased tumor cell apoptosis, and fully blocked or regressed myeloma tumors in mice[3].

1699750-95-2

C25H28Cl2N4O3

503.42

H2O:< 0.1 mg/mL (insoluble)
DMSO:75 mg/mL (148.98 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years