LDN-91946 是一种有效且特异性的泛素 C-末端水解酶-L1 (UCH-L1) 抑制剂（Ki = 2.8 μM）。

LDN-91946 is an effective and selective inhibitor of ubiquitin C-terminal hydrolase-L1 (UCH-L1) (Ki = 2.8 μM).

LDN-91946 shows no activity against TGase 2, Papain, and Caspase-3 at 40 μM. LDN-91946 is inactive against UCH-L3 at 20 μM. There is no cytotoxicity when serum-starved Neuro 2A (N2A) cells are treated with LDN-91946 at concentrations as high as 0.1 mM[1].

439946-22-2

C15H10N2O4S

314.32

DMSO:83 mg/mL (264.06 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years