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TT01001
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
TT01001图片
CAS NO:1022367-69-6
包装与价格:
包装价格(元)
1 mg电议
2 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
200 mg电议

产品名称
Ethyl 4-(3-(3,5-dichlorophenyl)thioureido)piperidine-1-carboxylate
TT-01001
产品介绍
TT01001 是 mitoNEET 的选择性激动剂,通过改善线粒体功能障碍来减少氧化应激损伤和神经元凋亡。 TT01001可用于治疗II型糖尿病的研究。

产品描述

TT01001 is a selective agonist of mitoNEET and reduces oxidative stress injury and neuronal apoptosis by improving mitochondrial dysfunction. TT01001 can be used in studies about the treatment of type II diabetes.

体内活性

In type II diabetes model db/db mice, TT01001 improved hyperglycemia, hyperlipidemia, and glucose intolerance, and its efficacy was equivalent to that of pioglitazone, without the pioglitazone-associated weight gain. Mitochondrial complex II + III activity of the skeletal muscle was significantly increased in db/db mice. TT01001 significantly suppressed the elevated activity of the complex II + III[2].

Cas No.

1022367-69-6

分子式

C15H19Cl2N3O2S

分子量

376.3

别名

Ethyl 4-(3-(3,5-dichlorophenyl)thioureido)piperidine-1-carboxylate;TT-01001

储存和溶解度

DMSO:18 mg/mL (47.8 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years