Levocetirizine Dihydrochloride ((R)-Cetirizine dihydrochloride) 是第三代 peripHERal H1-receptor 拮抗剂。Levocetirizine dihydrochloride 是一种抗组胺剂，是 Cetirizine 的 R 对映体。Levocetirizine dihydrochloride 对组胺 H1-受体的亲和力高于 (S)-Cetirizine，并且可用于研究变应性鼻炎和慢性特发性荨麻疹。

Levocetirizine Dihydrochloride ((R)-Cetirizine dihydrochloride) is a third-generation peripheral H1-receptor antagonist. Levocetirizine dihydrochloride is an antihistaminic agent which is the R-enantiomer of Cetirizine. Levocetirizine dihydrochloride has a higher affinity for the histamine H1-receptor than (S)-Cetirizine and can effectively treat allergic rhinitis and chronic idiopathic urticaria.

Levocetirizine (0.4 mg/kg; oral administration; male Sprague-Dawley rats) treatment shows that the Cmax, AUC0-t, AUC0-∞ and t1/2 are 0.34 μg/mL, 3.26 μg h/mL, 3.67 μg h/mL and 2.34 hours, respectively in Sprague-Dawley rats[1].

130018-87-0

C21H27Cl3N2O3

461.81

(-)-Cetirizine Dihydrochloride;Xyzal Dihydrochloride

DMSO:90mg/mL (194.9mM),Need ultrasonic
H2O:90mg/mL (194.9mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years