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RO2959 hydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
RO2959 hydrochloride图片
CAS NO:1219927-22-6
包装与价格:
包装价格(元)
1 mg电议
2 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议

产品名称
RO2959 HCl
产品介绍
RO2959 hydrochloride 是选择性CRAC通道抑制剂,IC50为 402 nM。它是人IL-2产生的有效抑制剂,有效阻断 T 细胞受体触发的基因表达和 T 细胞功能途径。它是由Orai1/Stim1通道介导的钙存储进入的有效阻滞剂,IC50为 25 nM。

产品描述

RO2959 hydrochloride is a potent and selective inhibitor of CRAC channel(IC50: 402 nM). It is also a potent inhibitor of human IL-2.

体外活性

RO2959 is a potent SOCE inhibitor that blocked an IP3-dependent current in CRAC-expressing RBL-2H3 cells and CHO cells stably expressing human Orai1 and Stim1, as well as SOCE in human primary CD4+ T cells triggered by either TCR stimulation or thapsigargin treatment. RO2959 completely inhibited cytokine production as well as T cell proliferation mediated by TCR stimulation or MLR (mixed lymphocyte reaction).

Cas No.

1219927-22-6

分子式

C21H20ClF2N5OS

分子量

463.93

别名

RO2959 HCl

储存和溶解度

DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years