ERDRP-0519 是一种有效的，具有口服活性的麻疹病毒 (MeV) 小分子聚合酶 (polymeRase) 抑制剂，可预防松鼠猴 (Saimiri sciureus) 的麻疹疾病。ERDRP-0519 以纳摩尔效力抑制麻疹病毒。

ERDRP-0519, an orally bioavailable small-molecule Measles virus (MeV) polymerase inhibitor, prevents measles disease in squirrel monkeys (Saimiri sciureus). ERDRP-0519 inhibits morbilliviruses with nanomolar potency.

ERDRP-0519 exhibits potency against a panel of Measles virus (MeV) isolates with EC50s of 0.07- 0.3 μM[1]. ERDRP-0519 exhibits potency against MeV and related pathogens of the Morbillivirus genus, such as canine distemper virus (CDV)[3].

A single-dose pharmacokinetic (PK) study is performed in squirrel monkeys by oral (intragastric) delivery of ERDRP-0519 (50 mg/kg) and blood sampling at seven predefined time points after dosing. Serum concentrations peak ~2 h post-administration (Cmax=3.27 μM)[3].

1374006-96-8

C23H30F3N5O4S

529.57

ERDRP0519;ERDRP 0519

DMSO:90mg/mL (169.9mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years