Procainamide 是 DNA 甲基转移酶 1 (DNMT1) 的特异性强效抑制剂。Procainamide是一种 1A 类抗心律失常药物。Procainamide 具有研究癌症和心律失常的潜力。

Procainamide is a specific and potent DNA methyltransferase 1 ( DNMT1 ) inhibitor. Procainamide is a Class 1A antiarrhythmic agent. Procainamide has the potential for the research of cancer and arrhythmias [1] [2].

HCT116, HCT116 DNMT1–/–, and HCT116 DNMT3b–/– cells were treated with PBS, pH 7.4 or 0.5 mM procainamide for 96 h. Procainamide treatment of HCT116 DNMT3b–/– cells decreased m5dC content by 11.5%, but treatment of HCT116 DNMT1–/– cells did not decrease m5dC content. These results suggested that DNMT1 was the intracellular target of procainamide[1].

51-06-9

C13H21N3O

235.33

Biocoryl;Novocainamide

DMSO:45mg/mL (191.2mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years