您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > CDDO-EA
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
CDDO-EA
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CDDO-EA图片
CAS NO:932730-51-3
包装与价格:
包装价格(元)
1 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
RTA 405
CDDO ethyl amide
TP319
产品介绍
CDDO-EA 是 Nrf2/抗氧化反应元件的激活剂。

产品描述

CDDO-EA is an activator of the Nrf2/antioxidant response element.

体外活性

In a cell culture model of ALS, CDDO-EA potently activates Nrf2/ARE [1]. CDDO-EA induces apoptosis in A549 lung cancer cells and induces heme oxygenase-1. CDDO-EA is 7-fold more potent than CDDO as a suppressor of the ability of IFN-γ to induce iNOS in RAW264.7 macrophage-like cells[2].

体内活性

CDDO-EA-treated G93A mice live significantly longer than the control. CDDO-EA increases the life-span from 124.05 days to 144.72 days (16.6%). In CDDO-EA-treated G93A mice, the age of death is 141.4 days and the duration from the age of onset to the age of death is 57.6 days. The age of death from the onset is prolonged by 17.5 days (43%) [1].

Cas No.

932730-51-3

分子式

C33H46N2O3

分子量

518.73

别名

RTA 405;CDDO ethyl amide;TP319

储存和溶解度

DMSO:30 mg/mL (57.8 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years