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Acumapimod
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Acumapimod图片
CAS NO:836683-15-9
包装与价格:
包装价格(元)
2 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
200 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
BCT-197
产品介绍
AcumaPimod 是一种有口服活性的p38 MAP激酶抑制剂,IC50值小于1 μM。

产品描述

Acumapimod is an orally active inhibitor of p38α MAPK (IC50<1 μM).

体内活性

Acumapimod increases survival and reduces the number of macrophages in bronchoalveolar lavage fluid (BALF) in a mouse model of infection with influenza H1N1 A/PR/8/34 when administered at a dose of 6 mg/kg[1]

动物实验

In vivo, female BALB/c mice were infected intranasally with 150 pfu of influenza H1N1 A/Puerto Rico/8/34 and treated with Acumapimod(BCT197) (a closely related p38 MAPK inhibitor with an IC50 value of<1?μM, currently in clinical testing), dexamethasone or oseltamivir (Tamiflu) starting 24?h post infection. Body weight, bronchoalveolar lavage cells, cytokines, total protein and lactate dehydrogenase as well as serum cytokines were measured; a subset of animals was evaluated histopathologically[1].

Cas No.

836683-15-9

分子式

C22H19N5O2

分子量

385.427

别名

BCT-197

储存和溶解度

DMSO:50 mg/mL (129.73 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years