(E/Z)-GSK5182 是 (E)-GSK5182 和 (Z)-GSK5182 的外消旋体。GSK5182 是一种具有高效选择性和口服活性的ERRγ的反向激动剂,其IC50值为 79 nM。GSK5182 还诱导肝癌细胞中活性氧 (ROS)的产生。
产品描述
(E/Z)-GSK5182 is a racemate of (E)-GSK5182 and (Z)-GSK5182 isomers. GSK5182 is a highly selective and orally active inverse agonist of estrogen-related receptor γ (ERRγ) with an IC 50 of 79 nM [1]. GSK5182 also induces reactive oxyen species (ROS) generation in hepatocellular carcinoma [1] [2] [3].
Cas No.
T7709
分子式
C27H31NO3
分子量
417.54
别名
GSK5182(Z/E)
储存和溶解度
DMSO:95 mg/mL (227.52 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years