您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > Tempol
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
Tempol
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CAS NO:2226-96-2
包装与价格:
包装价格(元)
50 mg电议
200 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
4-Hydroxy-TEMPO
Tanol
阻聚剂701
TMPN
产品介绍
Tempol 是一种超氧化物歧化酶类似物,可有效中和活性氧,具有抗炎、神经保护和镇痛作用。

产品描述

Tempol is a superoxide scavenger. It has anti-inflammatory, neuroprotective and analgesic effects.

体外活性

Tempol (4-Hydroxy-TEMPO) is a stable, cell-permeable nitroxide that acts as a free radical scavenger and nitric oxide spin trap. Tempol Exhibits radio-protective and anti-proliferative properties. Tempol inhibits oxygen-dependent radiation-induced damage. [1] Tempol induces oxidative stress and enhances the levels of p21WAF1 in HL-60 cells in a dose-dependent manner. [2]

体内活性

Tempol reduces oxidant stress-mediated renal dysfunction and injury in the rat. [3] Tempol prevents cerebral vessel remodeling in hypertensive rats. [4] Tempol lowers blood pressure and sympathetic nerve activity but not vascular O2- in DOCA-salt rats. [5] Tempol restores mitochondrial and cardiac functions in TNFα-induced oxidative stress and reduces cardiac hypertrophy in chronic hypoxic rats. [6]

细胞实验

The antiproliferative effect of Tempol is assessed by the MTT assay after 96 h exposure of the cells to the drug. Briefly, 100,000 cells/mL are seeded onto 96-well plates and allowed to grow for 24 h before treatment with different concentrations of Tempol (0.05–1.6 mM).(Only for Reference)

Cas No.

2226-96-2

分子式

C9H18NO2

分子量

172.24

别名

4-Hydroxy-TEMPO;Tanol;阻聚剂701;TMPN

储存和溶解度

Ethanol:17.2 mg/mL (100 mM)
DMSO:17.2 mg/mL (100 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years