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N-tert-butyl-α-Phenylnitrone
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
N-tert-butyl-α-Phenylnitrone图片
CAS NO:3376-24-7
包装与价格:
包装价格(元)
50 mg电议
100 mg电议
200 mg电议
500 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
N-叔丁基-α-苯基硝酮
(Z)-N-benzylidene-2-Methylpropan-2-aMine oxide
产品介绍
N-tert-Butyl-α-phenylnitrone 是基于硝酮的自由基清除剂,可形成一氧化氮自旋加合物。它可以穿透血脑屏障,抑制COX2的催化活性,有ROS清除、抗炎、神经保护、抗衰老和抗糖尿病的作用。

产品描述

N-tert-butyl-α-Phenylnitrone inhibits COX2 catalytic activity. N-tert-butyl-α-Phenylnitrone possesses potent reactive oxygen species scavenging, anti-inflammatory, neuroprotective, anti-aging, and anti-diabetic activities, and can penetrate the blood-brain barrier.

体外活性

Treatment of 25-100 μM N-tert-butyl-α-Phenylnitrone significantly reduces 2,2'-azobis (2-amidinopropane) dihydrochloride (AAPH)-induced intracellular ROS accumulation. N-tert-butyl-α-Phenylnitrone also attenuates AAPH-induced cytotoxicity, matrix degradation, and apoptosis, inhibiting AAPH-induced ERK/MAPK pathway activation[1].

体内活性

In C57Bl/6 mice induced by lipopolysaccharide (LPS), intraperitoneal injection of 100 mg/kg N-tert-butyl-α-Phenylnitrone twice a day (on gestational day 8) abolishes LPS-induced lipid peroxidation, nitrate tyrosine residue levels and GSH depletion, and reduces the incidence of external malformations[2].

Cas No.

3376-24-7

分子式

C11H15NO

分子量

177.24

别名

N-叔丁基-α-苯基硝酮;(Z)-N-benzylidene-2-Methylpropan-2-aMine oxide

储存和溶解度

DMSO:50 mg/Ml(282.10 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years