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SID 26681509
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
SID 26681509图片
CAS NO:958772-66-2
包装与价格:
包装价格(元)
1 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
1 mL*10 mM(in DMSO)电议

产品介绍
SID 26681509 是可逆的,竞争性的人组织蛋白酶 L选择性抑制剂,IC50为 56 nM。它抑制PlaSmodium falciparum的体外繁殖,IC50为15.4 μM,抑制Leishmania major,IC5012.5 μM。

产品描述

SID 26681509 is a selective, reversible and competitive human cathepsin L inhibitor (IC50 of 56 nM).

体外活性

After a 4 hr preincubation with cathepsin L, SID 26681509 becomes more potent(IC50 : 1.0 nM). SID 26681509 is determined to be a slow-binding and slowly reversible competitive inhibitor. Through a transient kinetic analysis for single-step reversibility, inhibition rate constants are kon = 24,000 M-1s-1 and koff = 2.2 × 10-5 s-1 (Ki = 0.89 nM). Molecular docking studies are undertaken using the experimentally-derived X-ray crystal structure of papain/CLIK-148[1]. SID 26681509 inhibits papain and cathepsins B, K, S, and V with IC50 values determined after one hour ranging from 618 nM to 8.442 μM[1].

体内活性

survival in murine models of sepsis significantly improved SID 26681509 by and reduces liver damage following warm liver ischemia/reperfusion (I/R) models[2].

Cas No.

958772-66-2

分子式

C27H33N5O5S

分子量

539.65

储存和溶解度

DMSO:55 mg/ml (101.92 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years