CCR2 antagonist 1 is a high-affinity and long-residence-time antagonist of CCR2 (Ki: 2.4 nM).

The combination of SAR and SKR in the hit-to-lead process results in the discovery of a new high-affinity and long residence time CCR2 antagonist 1 (compound 15a, Ki=2.4 nM; RT=714 min).

1683534-96-4

C28H32BrF3N2O

549.47

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years