(+)-FlupROStenol 是前列腺素 F2 α 的类似物,是一种前列腺素 F2α 受体 PTGFR 激动剂,可降低输卵管糖蛋白 1 (OVGP1) 的表达。
产品描述
(+)-Fluprostenol, an analogue of prostaglandin F2 alpha, is a prostaglandin F2α receptor PTGFR agonist and decreases the expression of Oviductal glycoprotein 1 (OVGP1).
体内活性
(+)-Fluprostenol(s.c. to rats on day 18 of pregnancy) increased cervical creep, or softness, by the following day. Doses of (+)-Fluprostenol 100-fold larger were necessary to increase uterine contractions. (+)-Fluprostenol produced falls in serum progesterone concentrations, increases in 20 alpha-dihydroprogesterone concentrations, no changes in oestradiol or relaxin concentrations and a reduction in the ovarian human chorionic gonadotrophin binding capacity in vitro. (+)-Fluprostenol was less potent in inducing cervical softness when administered per vaginam, and a dose which produced softening in pregnant rats was ineffective in ovariectomized steroid-maintained pregnant or pro-oestrous rats[3].
Cas No.
54276-17-4
分子式
C23H29F3O6
分子量
458.47
别名
Travoprost acid;曲伏前列素酸;Fluprostenol, (+)-;AL-5848
储存和溶解度
DMSO:325 mg/mL (708.88 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years