您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > E7046
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
E7046
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
E7046图片
CAS NO:1369489-71-3
包装与价格:
包装价格(元)
50 mg电议
100 mg电议

产品介绍
E7046 是一种口服有效的特异性EP4拮抗剂,IC50值为 13.5 nM,Ki值为 23.14 nM,具有抗肿瘤活性。

产品描述

E7046 is a specific, orally bioavailable EP4 antagonist (IC50: 13.5 nM, Ki: 23.14 nM), exhibiting anti-tumor activities.

体外活性

Through selective EP4 antagonism, E7046 reverses the immunosuppressive effects of PGE2 on activation and differentiation of human myeloid cells [1].

体内活性

E7046 (150 mg/kg) inhibits the growth of multiple syngeneic tumor models. The blockade of EP4 signaling promotes anti-tumor DC differentiation and slows tumor growth in mice. E7046 treatment reduces the growth or even rejected established tumors in vivo in a manner dependent on both myeloid and CD8C T cells [1]. In the CT-26 tumor model, the E7046/RT combination causes the anti-tumor memory response of 9 animals. In the 4T1 model, the combination of E7046 and RT also produces significantly better tumor growth inhibition activity compared with each treatment alone. The combination significantly improves survival by inhibiting the subsequent spontaneous lung metastasis of 4T1 tumors [2].

Cas No.

1369489-71-3

分子式

C22H18F5N3O4

分子量

483.395

储存和溶解度

DMSO:100 mg/mL (206.87 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years