FIDAS-3 是一种强效Wnt抑制剂,也是一种二苯乙烯衍生物,对甲硫氨酸腺苷转移酶 2A (MAT2A) 的IC50为 4.9 μM。它能够与 S-腺苷甲硫氨酸有效竞争MAT2A结合,并具有抗癌作用。
产品描述
FIDAS-3 effectively competes against S-adenosylmethionine (SAM) for MAT2A binding. FIDAS-3 has anticancer activities. FIDAS-3 is a stilbene derivative and is a potent Wnt inhibitor with an IC50 of 4.9 μM for methionine S-adenosyltransferase 2A (MAT2A).
体外活性
FIDAS-3 induces the expression of cell cycle inhibitor, p21WAF1/CIP1.?FIDAS-3 (10 μM;?36 h) treatment reduces the levels of both S-adenosylmethionine (SAM) and S-adenosylhomocysteine (SAH) in LS174T cells.FIDAS-3 (3 μM; 7 days; LS174T cells) treatment significantly inhibits the proliferation of LS174T cells. FIDAS-3 (3-10 μM) treatment inhibits the expression of c-Myc and cyclinD1 in LS174T CRC cells.
体内活性
FIDAS-3 (20 mg/kg;?intraperitoneal injection;?daily;?for one months;?C57BL/6J athymic nude mice) treatment significantly inhibits the growth of xenograft tumors.
Cas No.
1266684-01-8
分子式
C16H15F2N
分子量
259.29
储存和溶解度
DMSO:90mg/ml(347.10mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years