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Adavivint
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Adavivint图片
CAS NO:1467093-03-3
包装与价格:
包装价格(元)
1 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议

产品名称
Adavivint (SM04690)
产品介绍
Adavivint (SM04690) 是选择性的典型的Wnt信号通路抑制剂,在 SW480 细胞中,用高通量 TCF/LEF 报告基因实验,测得EC50=19.5 nM。

产品描述

Adavivint (SM04690) is a Wnt pathway inhibitor.

体内活性

Adavivint (SM04690) is a?novel Wnt pathway inhibitor, for the treatment of moderate to severe osteoarthritis of the knee.

动物实验

A high-throughput screen was performed using a cell-based reporter assay for Wnt pathway activity to develop a small molecule designated SM04690. Its properties were evaluated in bone-marrow-derived human mesenchymal stem cells (hMSCs) to assess chondrocyte differentiation and effects on cartilage catabolism by immunocytochemistry and gene expression, and glycosaminoglycan breakdown. In vivo effects of SM04690 on Wnt signaling, cartilage regeneration and protection were measured using biochemical and histopathological techniques in a rodent acute cruciate ligament tear and partial medial meniscectomy (ACLT + pMMx) OA model.

Cas No.

1467093-03-3

分子式

C29H24FN7O

分子量

505.557

别名

Adavivint (SM04690)

储存和溶解度

DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years