JW 67 是典型Wnt信号通路的抑制剂,IC50为 1.17 μM。它影响由 β- 连环蛋白/GSK-3β/AXIN/APC/CK1 组成的多蛋白复合物,快速降低活性 β- 连环蛋白,随后下调Wnt靶基因。它也抑制结直肠癌细胞生长。
产品描述
JW 67 is an inhibitor of canonical Wnt pathway signaling. JW 67 rapidly reduced active β-catenin with a subsequent downregulation of Wnt target genes, including AXIN2, SP5, and NKD1.
体外活性
JW 67 inhibits the canonical?Wnt?signaling with an?IC50?of 1.17μM[1]. JW 67 (1 μM) increased concentration of AXIN2 and decreased the active form of β-catenin[1]. JW 67 (10 or 25μM) reduced growth of SW480 CRC cells in vitro by inhibiting cell-cycle progression at the G1/S[1].
Cas No.
442644-28-2
分子式
C21H18N2O6
分子量
394.38
储存和溶解度
DMSO:<39.44mg/ml
Powder: -20°C for 3 years
In solvent: -80°C for 2 years