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Halofuginone hydrobromide
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Halofuginone hydrobromide图片
CAS NO:64924-67-0
包装与价格:
包装价格(元)
2 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
200 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
Tempostatin
卤夫酮溴氢酸盐
常山酮溴酸盐
Stenorol
RU-19110 (hydrobromide)
产品介绍
Halofuginone hydrobromid是Febrifugine 的衍生物,是竞争性脯氨酰-tRNA 合成酶抑制剂。它是 I 型胶原合成的特异性抑制剂,并通过抑制TGF-β活性可减轻骨关节炎。它具有抗疟疾、抗炎、抗癌、抗纤维化作用。

产品描述

Halofuginone specifically inhibits collagen type I gene expression and matrix metalloproteinase 2 (MMP-2) gene expression, which may result in the suppression of angiogenesis, tumor stromal cell development, and tumor cell growth. Halofuginone Hydrobromide is the hydrobromide salt of halofuginone, a semisynthetic quinazolinone alkaloid anticoccidial derived from the plant Dichroa febrifuga, with antifibrotic and potential antineoplastic activities. These effects appear to be due to halofuginone-mediated inhibition of the collagen type I and MMP-2 promoters. Collagen type I and MMP-2 play important roles in fibroproliferative diseases.

Cas No.

64924-67-0

分子式

C16H18Br2ClN3O3

分子量

495.6

别名

Tempostatin;卤夫酮溴氢酸盐;常山酮溴酸盐;Stenorol;RU-19110 (hydrobromide)

储存和溶解度

DMSO:49.6 mg/mL (100 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years