TP0427736 是一种有效的选择性 ALK5 抑制剂，IC50 为 2.72 nM，比对 ALK3 的抑制作用高 300 倍。 TP0427736 可降低人外根鞘细胞中 TGF-β 诱导的生长抑制，并延长小鼠毛囊中的生长期。

TP0427736 is a potent and selective inhibitor of ALK5 with an IC50 of 2.72 nM, 300-fold higher than the inhibitory effect on ALK3. TP0427736 reduces TGF-β-induced growth inhibition in human outer root sheath cells and elongates the anagen phase in mouse hair follicles.

864374-00-5

C14H10N4S2

298.39

TP427736;TP-0427736;TP-427736

DMSO:65 mg/ml (217.84 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years