Droloxifene，Tamoxifen 衍生物，是一种具有口服活性和选择性的雌激素受体 (estrogen receptor) 调节剂。Droloxifene 具有抗雌激素和抗植入作用。Droloxifene 诱导 MCF-7 细胞 p53 表达及凋亡。Droloxifene 预防去卵巢大鼠骨丢失。

Droloxifene, a tamoxifen derivative, is an oral active and selective estrogen receptor modulator.Droloxifene induced p53 expression and apoptosis in McF-7 cells.Fluroxifene has anti-estrogen and anti-implantation effects.Fluroxifene prevented bone loss in ovariectomized rats.

Droloxifene induces apoptosis in MCF-7 cells(10 nM; 16-18 hours)[1].

Droloxifene (5-20 mg/kg,P.o.;Daily for 4 weeks can bring THE BMD of DFM up to 10mg/kg and completely prevent OVX from reducing the BMC and BMD of DFM at 20mg /kg/day[1].

82413-20-5

C26H29NO2

387.51

3-Hydroxytamoxifen

DMSO:45.0 mg/mL (116.1 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years