JAK-IN-11是JAK的强效选择性抑制剂,具有治疗皮肤疾病的潜力。
产品描述
JAK-IN-11 is a potent and selective inhibitor of JAK, has the potential for the skin disorders treatment.
体外活性
JAK/STAT signaling has been implicated in the mediation of many abnormal immune responses such as allergies, asthma, autoimmune diseases such as transplant rejection, rheumatoid arthritis, amyotrophic lateral sclerosis and multiple sclerosis, ocular disorders and diseases, as well as in solid and hematologic malignancies such as leukemia and lymphomas[1].
Cas No.
916742-11-5
分子式
C23H22FN5O4S
分子量
483.52
别名
R-348
储存和溶解度
(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years