Tauroursodeoxycholate sodium是一种内质网应激抑制剂。Tauroursodeoxycholate 抑制ERK，显著降低凋亡分子表达，如Caspase-3和Caspase-12。

Tauroursodeoxycholate Sodium is an endoplasmic reticulum (ER) stress inhibitor, used for the treatment of gallstones and liver cirrhosis.

In phalloidin-induced cholestasis rats, Tauroursodeoxycholate (360 μmol/kg, i.v.) significantly suppresses the decrease in bile flow and increases in serum alkaline phosphatase, leucine aminopeptidase and glutamic pyruvic transaminase activities, cholesterol, phospholipid and bile acid concentrations. [2]

Cell lines: Mz-ChA-1 cells. Concentrations: ~200 μM. Method: After trypsinization,Mz-ChA-1 cells are suspended in CCM at 5×104 cells/mL,and 200 μL of the cell suspension is seeded into 96-well plates.After an initial incubation step of 4 h at 37°C in a 5% CO2 incubator,the cells are incubated at 37°C with TUDCA (0.2–200 μM).After incubation for 24–96 h,[3H]thymidine is put into each well at 5.0 μCi/mL and incubated for additional 4 h.[3H]thymidine incorporation is measured by a scintillation counter.

Animal Models: Phalloidin-induced cholestasis ratsFormulation & . Dosages: Saline; 360 μMol/kg. Administration: intravenous injection

35807-85-3

C26H44NNaO6S

521.69

Tauroursodeoxycholic acid sodium salt;牛磺熊去氧胆酸钠;牛磺熊脱氧胆酸钠;TUDC;Sodium tauroursodeoxycholate;Sodium Tauroursodeoxycholate (TUDC)

Ethanol:10 mg/mL(19.2 mM)
DMSO:93 mg/mL (178.3 mM)
H2O:92 mg/mL (176.3 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years