KEA1-97 是一种选择性硫氧还蛋白-半胱天冬酶 3相互作用干扰剂，IC50为10 μM。它在不影响硫氧还蛋白活性的情况下, 破坏硫氧还蛋白与 Caspase 3 的相互作用，激活半胱天冬酶，诱导细胞凋亡。

Kea1-97 is a selective disruptor of interaction between thioredoxin and caspase-3 (IC50 = 10 μ M). Kea1-97 destroys the interaction between thioredoxin and caspase 3 and activates caspases without affecting the activity of thioredoxin.

KEA1-97 (10 μM, 48h) impaired 231MFP cell survival and proliferation and does not affect viability in MCF10A cells.

KEA1–97 treatment (5 mg/kg ip once per day) was initiated 16 days after the initiation of 231MFP tumor xenografts in immune-deficient SCID mice.

2138882-71-8

C15H9Cl2FN4

335.16

DMSO:90mg/ml(268.53mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years