Caspase-3 Inhibitor I 是 Caspase-3 的特异性抑制剂。

Caspase-3 Inhibitor I is a specific inhibitor of Caspase-3.

Pretreatment with the caspase-3 inhibitor Ac-DEVD-CHO or antioxidant NAC blocked SLNT-induced apoptosis[1]. The apoptosis of SP2/0 cells was blocked by a pan-caspase inhibitor Z-VAD-FMK and caspase-3 inhibitor Ac-DEVD-CHO[2].

Compared with model group, in CI group, the concentrations of serum BUN were decreased significantly at all time points after operation and those of Cr were decreased significantly at 6 hours, then restored to those of the sham group at 12 hours and 24 hours; the concentrations of serum TNF-α, IL-6 were decreased and those of IL-10 elevated significantly at all time points[3].

TQ0146L

C22H34N4O13

562.52

N-acetyl-asp-glu-val-asp-al;乙酰基-天冬氨酰-谷氨酰-缬氨酰-天冬氨醛;Ac-DEVD-CHO acetate (169332-60-9 free base)

H2O:40 mg/mL (79.61 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years