Boc-D-FMK 是一种可渗透细胞,不可逆的泛半胱天冬酶抑制剂。它抑制 TNF-α 诱导的细胞凋亡的IC50值为 39 μM。
产品描述
Boc-D-FMK is an irreversible, cell-permeable, and broad-spectrum caspase inhibitor and inhibits apoptosis stimulated by TNF-α (IC50: 39 μM).
体外活性
Boc-D-fmk inhibits TNFα-stimulated reactive oxygen species (ROS) generation [1]. Boc-D-fmk (50 μM) prevents genistein-induced apoptosis of p815 cells. The release of mitochondrial apoptotic factors is inhibited by Boc-D-fmk [2].
体内活性
Boc-D-FMK-fmk effectively attenuates the hepatocyte apoptosis in bile duct-ligated rats and may improve the survival rates after the endotoxin challenge [3]. Boc-D-FMK (single injection) results in longterm protection of MNs against root avulsion-induced death for more than 8 weeks and the Boc-D-FMK-treated MNs are able to regenerate their axons into an implanted PN graft and reinnervate the target muscle [4].
Cas No.
634911-80-1
分子式
C11H18FNO5
分子量
263.26
储存和溶解度
DMSO:125 mg/mL (474.82 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years