EF24 是姜黄素类似物，口服生物利用度高，抗肿瘤作用强。它可增强活化的 Caspase3 及 Caspase9 的水平，并抑制 MEK1 及 ERK 的磷酸化形式的表达。它可以抑制口腔鳞状细胞癌细胞的 MAPK/ERK 信号通路，从而发挥抗肿瘤作用。

EF24 treatment increases the levels of activated caspase 3 and 9, and decreases the phosphorylated forms of MEK1 and ERK. EF24 shows potent anti-tumor activity in oral squamous cell carcinoma (OSCC) via deactivation of the MAPK/ERK signaling pathway.

342808-40-6

C19H15F2NO

311.33

EF-24;EF 24;3,5-Bis[(2-fluorophenyl)Methylene]-4-piperidinone

DMSO:10mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years