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CTX1
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CTX1图片
CAS NO:501935-96-2
包装:25 mg
市场价:8877元

产品介绍

产品描述

CTX1 is a small molecule activator of p53.

体外活性

CTX1 can induce p53 protein levels in the p53 mutant cell line, HT29 and it also induces significant p53-dependent cell death preferentially in HdmX-expressing cells as compared to cells in which p53 is inactivated by Hdm2 overexpression or p53 is knocked down using p53 targeting shRNA. It is also found that CTX1 shows potent activity (LD50 ~1 μM) as a single agent on primary AML patient samples in a similar fashion to AML cell lines. After CTX1(16 h) treatment in HCT116 p53-wild-type cells, there is a decrease in S phase from 23% to 3% while HCT116 p53-null cells exhibit a reduction in S phase from 34% to 28%. The combination of low doses of CTX1 and nutlin-3 leads to a significant enhancement of apoptosis in p53-wildtype, but not p53-null cells.

体内活性

Mice treated with CTX1 alone or in combination with nutlin-3 has a significantly increased survival time (p<0.0001). In this model system, CTX1 even as a single agent significantly enhances the survival of mice.

Cas No.

501935-96-2

分子式

C14H10N4

分子量

234.26

储存和溶解度

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years