GSK840 是受体相互作用蛋白激酶 3(RIP3 或 RIPK3)的有效抑制剂,与RIP3 激酶结构域高亲和力结合 ,IC50为 0.9 nM,并抑制激酶活性,IC50为 0.3 nM。
产品描述
GSK840 is a receptor-interacting protein kinase 3 (RIP3 or RIPK3) inhibitor, which binds the RIP3 kinase domain (IC50: 0.9 nM), and inhibits kinase activity (IC50: 0.3 nM).
体外活性
In human HT-29 cells, GSK840 (0.01-3 μM) blocked TNF-induced necroptosis in a concentration-dependent manner. GSK840 binded the kinase domain and inhibited kinase activity with high specificity, targeting a broader range of pro-necrotic stimuli[1].
Cas No.
2361146-30-5
分子式
C21H23N3O3
分子量
365.43
别名
GSK'840
储存和溶解度
DMSO:110 mg/mL (301.02 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years