产品描述
MI-1061 is a orally bioavailable inhibitor of MDM2 (MDM2-p53 interaction) (IC50=4.4 nM).
体外活性
MI-1061 achieves IC50 of 100 and 250 nM in the SJSA-1 and HCT-116 p53+/+ cell lines, respectively[1].
体内活性
MI-1061 was able to achieve tumor regression in oral SJSA-1 xenograft model mice[1].
Cas No.
1410737-34-6
分子式
C30H26Cl2FN3O4
分子量
582.45
储存和溶解度
DMSO:300 mg/mL (515.07 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years