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MG-277
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
MG-277图片
包装与价格:
包装价格(元)
100 mg电议
500 mg电议

产品介绍

产品描述

MG-277 is a molecular glue compound transformed from PROTAC degradation agent, MG-277 potently inhibits tumor cell growth in a p53-independent manner.

体外活性

MG277 has a significantly decreased potency in reducing the level of MDM2 protein in cells and fails to activate wild-type p53. MG-277 is highly potent and effective in inhibition of cell growth in cancer cell lines with wild-type p53, mutated p53, or deleted p53, indicating a p53-independent mechanism. MG-277 induces rapid GSPT1 degradation in cancer cells in a p53- and MDM2-independent manner but in a manner dependent upon cereblon, CUL4 E3 ubiquitin ligase, and proteasomes[1].

Cas No.

T12027

分子式

C41H42Cl2FN5O5

分子量

774.71

储存和溶解度

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years