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BT-13
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
BT-13图片
CAS NO:924537-98-4
包装与价格:
包装价格(元)
2 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
200 mg电议
1 mL*10 mM(in DMSO)电议

产品介绍
BT-13 是一种胶质细胞源性神经营养因子 (GDNF) 受体 RET的选择性激动剂,独立于 GDNF 配体发挥作用,能够促进体外感觉神经元神经突生长,减少大鼠神经病变的发生。

产品描述

BT-13 is a selective agonist of glial cell line-derived neurotrophic factor (GDNF) receptor RET independently of GFLs. BT-13 promotes neurite growth from sensory neurons in vitro.

体外活性

BT-13 stimulates phosphorylation of RET and RET-dependent intracellular signaling but activated neither BDNF receptor TrkB nor NGF receptor TrkA nor intracellular signaling in the absence of RET.

体内活性

In rats with surgery-induced neuropathy, BT-13 (20 and 25mg/kg in rats induced by ligation of left L5 and L6 spinal nerves) has a slight antinociceptive/antihyperalgesic effect and protected DRG neurons.

Cas No.

924537-98-4

分子式

C23H27F4N3O4S

分子量

517.54

储存和溶解度

DMSO:25 mg/mL (48.31 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years