BT-13 是一种胶质细胞源性神经营养因子 (GDNF) 受体 RET的选择性激动剂，独立于 GDNF 配体发挥作用，能够促进体外感觉神经元神经突生长，减少大鼠神经病变的发生。

BT-13 is a selective agonist of glial cell line-derived neurotrophic factor (GDNF) receptor RET independently of GFLs. BT-13 promotes neurite growth from sensory neurons in vitro.

BT-13 stimulates phosphorylation of RET and RET-dependent intracellular signaling but activated neither BDNF receptor TrkB nor NGF receptor TrkA nor intracellular signaling in the absence of RET.

In rats with surgery-induced neuropathy, BT-13 (20 and 25mg/kg in rats induced by ligation of left L5 and L6 spinal nerves) has a slight antinociceptive/antihyperalgesic effect and protected DRG neurons.

924537-98-4

C23H27F4N3O4S

517.54

DMSO:25 mg/mL (48.31 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years