DL-Buthionine-(S,R)-sulfoximine 是 γ-谷氨酰半胱氨酸合成酶的抑制剂，用于治疗实体瘤。

D,L-Buthionine-(S,R)-sulfoximine is an inhibitor of γ-glutamylcysteine synthetase for the treatment of solid tumors.

D,L-Buthionine-(S,R)-sulfoximine (32 mmol/kg, i.p.) reduces renal glutathione in mice without inducing abnormal behavior or convulsions.?It has antiparasitic activity, eliminating T. brucei from the bloodstream of infected mice via depletion of intratrypanosomal glutathione and induction of oxidative stress at a dose of 4 mmol/kg[1].

5072-26-4

C8H18N2O3S

222.3

丁基硫;NSC 381100;D,L-Buthionine-(S,R)-sulfoximine;Butionine sulfoximine

H2O:10 mM
DMSO:Insoluble
Powder: -20°C for 3 years
In solvent: -80°C for 2 years