BPAM344 是一种红藻氨酸受体亚基GluK1b、GluK2a和GluK3a的正变构调节剂。

BPAM344 is a potent positive allosteric modulator (PAM) of the KAR subunits GluK1b, GluK2a, and GluK3a.

BPAM344 potentiated glutamate-evoked currents of GluK2a 21-fold at the highest concentration tested (200 μM), with an EC50 of 79 μM. BPAM344 markedly decreased desensitization kinetics (from 5.5 to 775 ms). BPAM521 potentiated the recorded peak current amplitude of GluK2a 12-fold at a concentration of 300 μM with an EC50 value of 159 μM. BPAM344 (100 μM) potentiated the peak current amplitude of KAR subunits GluK3a (59-fold), GluK2a (15-fold), GluK1b (5-fold), as well as the AMPA receptor subunit GluA1i (5-fold)[1].

1204572-55-3

C10H11FN2O2S

242.27

DMSO:55 mg/ml (227.02 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years