YM90K hydrochloride 是一种选择性的、有效的AMPA受体拮抗剂，Ki=84 nM。YM90K 抑制海藻酸酯 (Ki为 2.2 μM) 和 NMDA (Ki为 37 μM) 受体的效力较低，并具有神经保护活性。

YM90K hydrochloride is an antagonist of AMPA receptor.

In a global ischemia model, YM90K (15 mg/kg i.p. x 3), NBQX (30 mg/kg i.p. x 3) and CNQX (60 mg/kg i.p. x 3) significantly prevented the delayed neuronal death in the hippocampal CA1 region in Mongolian gerbils when administered 1 h after 5-min ischemia.?In addition, the therapeutic time window for the neuroprotective effect of YM90K (30 mg/kg i.p. x 3) was 6 h. In a focal ischemia model, YM90K (30 mg/kg i.v. bolus+10 mg/kg/h for 4 h) reduced the volume of ischemic damage in the cerebral cortex in F344 rats[1].

154164-30-4

C11H8ClN5O4

309.67

1,4-二氢-6-(1H-咪唑-1-基)-7-硝基-2,3-喹喔啉二酮单盐酸盐;6-(1H-imidazol-1-yl)-7-nitro-2,3(1H,4H)-;YM90K hydrochloride

DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years