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Tamsulosin hydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Tamsulosin hydrochloride图片
CAS NO:106463-17-6
包装与价格:
包装价格(元)
25 mg电议
50 mg电议
100 mg电议
200 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
Flomax hydrochloride
盐酸坦索罗辛
Flomax
产品介绍
Tamsulosin hydrochloride 是一种 α1肾上腺素能受体 (α1-Adrenergic Receptor) 抑制剂。在动物模型中,它可减缓腹主动脉瘤的生长。它常用于前列腺增生的研究。

产品描述

Tamsulosin Hydrochloride is the hydrochloride salt of tamsulosin, a sulfonamide derivative with α1 adrenergic antagonist activity.

体内活性

Tamsulosin exhibits high plasma-protein binding, largely to α1-acid glycoprotein. It is metabolized, mainly by cytochrome P450 (CYP) 3A4 and CYP2D6 to compounds with low abundance, and 8.7–15% of an oral dose is excreted renally as the parent compound. The pharmacokinetics of tamsulosin are not affected to a major extent by age, and pharmacokinetic alterations in renally impaired patients relate largely to an increased concentration of α1-acid glycoprotein. Pharmacokinetic alterations with hepatic impairment are also only moderate, thus neither renal nor mild to moderate hepatic impairment necessitates dose adjustment. Early studies of tamsulosin IR in experimental animals, such as rats and dogs, showed rapid absorption of tamsulosin after oral administration (within 30–90 minutes) but absolute bioavailability of only 7–23% in rats and 30–42% in dogs. The absolute bioavailability of tamsulosin MR in fasted humans is approximately 100%. The tmax is typically about 5 hours (reported range of mean values 2.9-5.6 hours) in the fasted state and about 6 hours in the fed state (range 5.2-7.0 hours). Animal studies involving intravenous injection of radiolabelled tamsulosin and measurement of radiolabel in various tissues after 10 minutes have shown the presence of the drug in various tissues, ranked in the following order: kidney>lung≈heart>submaxillary gland>liver ≈spleen≈aorta≈vas deferens>prostate>>cerebral cortex, the latter being close to detection limits. Tamsulosin may not pass the blood-brain barrier.

Cas No.

106463-17-6

分子式

C20H29ClN2O5S

分子量

444.97

别名

Flomax hydrochloride;盐酸坦索罗辛;Flomax

储存和溶解度

DMSO:44.5 mg/mL (100 mM)
H2O:4.5 mg/mL (10 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years