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Propranolol hydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Propranolol hydrochloride图片
CAS NO:318-98-9
包装与价格:
包装价格(元)
25 mg电议
50 mg电议
100 mg电议
200 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
Propranolol HCl
NCS-91523
ICI-45520
AY-64043
盐酸普萘洛尔
产品介绍
Propranolol hydrochloride 是非选择性的β-Adrenergic Receptor拮抗剂,对 β1AR 和 β2AR 具有高亲和力。它能够抑制 [3H]-DHA 与大鼠脑膜制剂的结合。它可以用于研究高血压,嗜铬细胞瘤,心肌梗塞,心律不齐,心绞痛和肥大心肌病。

产品描述

Propranolol hydrochloride is a widely used non-cardioselective beta-adrenergic antagonist. Propranolol has been used for MYOCARDIAL INFARCTION; ARRHYTHMIA; ANGINA PECTORIS; HYPERTENSION; HYPERTHYROIDISM; MIGRAINE; PHEOCHROMOCYTOMA; and ANXIETY but adverse effects instigate replacement by newer drugs.

体外活性

In cultured endothelial or tumor cells, propranolol has been shown to both reduce cAMP levels and simultaneously activate the mitogen-activated protein kinase (MAPK) pathway downstream of βAR inhibition[2]. It displays high affinity for 5-HT1B receptors (Ki= 17 nM), and milder affinity for 5HT1D receptors (Ki= 10.2 μM)[3].

体内活性

Chronic administration of propranolol increased the beta(1)-adrenoceptors but decreased the beta(2)-adrenoceptors without changing total amount of plasma membrane beta-adrenoceptors[4].

Cas No.

318-98-9

分子式

C16H22ClNO2

分子量

295.81

别名

Propranolol HCl;NCS-91523;ICI-45520;AY-64043;盐酸普萘洛尔

储存和溶解度

H2O:6 mg/mL (20.28 mM)
DMSO:55 mg/mL (185.9 mM)
Ethanol:<1 mgml
Powder: -20°C for 3 years
In solvent: -80°C for 2 years