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Norepinephrine bitartrate monohydrate
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Norepinephrine bitartrate monohydrate图片
CAS NO:108341-18-0
包装与价格:
包装价格(元)
200 mg电议
500 mg电议
1 g电议
1 mL*10 mM(in DMSO)电议

产品名称
酒石酸去甲肾上腺素
降肾上腺素
Noradrenaline bitartrate monohydrate
Levophed
产品介绍
Noradrenaline bitartrate monohydrate 是一种β1-选择性的肾上腺素能受体激动剂,EC50为 5.37 μM。

产品描述

Noradrenaline bitartrate monohydrate is a direct alpha-adrenergic receptors stimulator.

体外活性

Noradrenaline modulates the gain of evoked activity, especially in sensory areas. Noradrenaline promotes long-term synaptic plasticity, in addition to these data emphasizing its short-term influence. Noradrenaline would signal ‘gross changes in the environment that produce sensory information strongly violating top-down expectations' and would, through an enhancement of ‘bottom-up' information processing at the expense of irrelevant ‘top-down' expectations, favor behavioral adjustment. [1] Noradrenaline modulates drive and energy and exerts a fine regulation of specific processes including learning, memory, sleep, arousal and adaptation. Noradrenaline system is intimately involved in a range of psychological processes which, when disrupted, lead to the expression of classifiable psychiatric disorders. Noradrenaline appears to be involved in a range of psychological processes, including arousal (vigilance), cognition, learning and sleep regulation, and also in regulating response to stressors which might initiate or exacerbate depressive symptomatology. Noradrenaline deficiency in this pathway may reduce concentration, affect working memory and cause psychomotor retardation, resulting in apathy and depression,while an increase in noradrenaline in this pathway is predicted to alleviate poor concentration, apathy and depression. [2] Noradrenaline effects are complex and depending on experimental conditions (ponto-medullary and medullary preparations) and species (rats or mice), exogenous Noradrenaline mainly facilitates or mainly inhibits the neonatal RRG, with a mixture of α1 facilitatory and α2 inhibitory effects. [3]

细胞实验

Norepinephrine (NE)is dissolved in DMSO and stored, and then diluted with appropriate media before use[2]. Subcutaneous preadipocytes derived from a 38-year old non-diabetic female donor are immortalized with TERT and HPV E6/E7. For the current studies, a stable diploid clone (referred to as clone B) with consistent differentiation capacity is isolated by ring cloning. Cells are grown in preadipocyte PGM2 media. Once cells are confluent, differentiation is induced by incubation in differentiation media consisting of dexamethasone, IBMX, indomethacin, and additional insulin. Cells are differentiated for 10 days. Prior to treatment, media is replaced with PGM2 media for one day and then switched to serum-free media overnight for treatments. Adipocytes are treated for 6 hours with vehicle, Norepinephrine (NE, 10 μM), CGP (10 nM), or Norepinephrine (NE) and CGP[2].

Cas No.

108341-18-0

分子式

C12H19NO10

分子量

337.281

别名

酒石酸去甲肾上腺素;降肾上腺素;Noradrenaline bitartrate monohydrate;Levophed

储存和溶解度

H2O:31.9 mg/mL (100 mM)
DMSO:31.9 mg/mL (100 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years