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Sertindole
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Sertindole图片
CAS NO:106516-24-9
包装与价格:
包装价格(元)
5 mg电议
10 mg电议
50 mg电议
100 mg电议
200 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
Lu 23-174
舍吲哚
产品介绍
Sertindole 是一种非典型抗精神病药,可与多巴胺 D2 受体和血清素受体亚型 5-HT1D、5-HT2A 和 5-HT2C 结合,Kd值分别为 2.7、20、0.14 和 6 nM。

产品描述

Sertindole is an atypical antipsychotic that binds to dopamine D2 receptors and the serotonin (5-HT) receptor subtypes 5-HT1D, 5-HT2A, and 5-HT2C (Kds = 2.7, 20, 0.14, and 6 nM, respectively)

体内活性

In vivo, sertindole (10 mg/kg) increases extracellular dopamine, acetylcholine (ACh), and glutamate levels in the medial prefrontal cortex in conscious rats[1].Sertindole (2.5 mg/kg) reverses ketamine-induced impairments in the extradimensional shift stage of the attentional set-shifting task (ASST) in rats[2].It reverses phencyclidine (PCP)-induced selective reversal learning deficits in rats and subchronic PCP-induced deficits in the novel object recognition task in mice[3].

动物实验

Rats were treated acutely with vehicle or drugs, and extracellular levels of neurotransmitters were assessed by microdialysis in freely moving animals[1].

Cas No.

106516-24-9

分子式

C24H26ClFN4O

分子量

440.94

别名

Lu 23-174;舍吲哚

储存和溶解度

DMSO:50 mg/mL (113.39 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years