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ONC206
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
ONC206图片
CAS NO:1638178-87-6
包装与价格:
包装价格(元)
2 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
200 mg电议
1 mL*10 mM(in DMSO)电议

产品介绍
ONC206 是一种 ONC201 的类似物,是一种多巴胺 D2- 样受体 (DRD2/3/4) 的选择性拮抗剂,其拮抗作用在纳摩尔级别。它具有广谱抗肿瘤活性。

产品描述

ONC206 is an analogue of TRAIL inducer ONC201 and is a selective antagonist of the D2-like dopamine receptors (DRD2/3/4) at nanomolar concentrations. ONC206 also has broad-spectrum anti-tumor activity.

体外活性

ONC206 (Oncoceutics) is an imipiridone with nanomolar potency and analogue of ONC201, a selective dopamine receptor D2 (DRD2) antagonist currently being investigated in phase II clinical trials for serous endometrial cancer (SEC).??ONC206 inhibited cellular proliferation in a dose-dependent manner and was more potent than ONC201 in the ARK1 (IC50 = 0.33 M vs. IC50 = 1.59uM) and SPEC-2 (IC50 = 0.24uM vs. IC50 = 0.81uM) cell lines.?Treatment with ONC206 resulted in induction of ROS production and reduction of mitochondrial membrane potential, accompanied by an increase in cleaved caspase-3 and caspase-9 activity (p

体内活性

ONC206 (100 mg/kg; p.o.; every 10 days) reduces obviously tumor growth inhibition[2].

Cas No.

1638178-87-6

分子式

C23H22F2N4O

分子量

408.44

储存和溶解度

DMSO:100 mg/mL (244.83 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years