Trimethobenzamide hydrochloride 是一种多巴胺D2受体阻断剂,是一种止吐剂,用于预防恶心和呕吐。
产品描述
Trimethobenzamide hydrochloride is a blocker of the D2 receptor. Trimethobenzamide is an antiemetic used to prevent nausea and vomiting.
体外活性
Trimethobenzamide is a (non-phenothiazine) benzamide antiemetic that acts centrally to block D2 receptors, thus inhibiting the medullary chemoreceptor trigger zone via blocking emetic impulses to the vomiting center.
体内活性
The oral bioavailability of Trimethobenzamide is 60% to 100%. The peak time is about 45 minutes after oral administration and; Intramuscular (I.M.) administration about 30 minutes after intramuscular administration
Cas No.
554-92-7
分子式
C21H29ClN2O5
分子量
424.92
别名
盐酸三甲氧苯酰胺;Ro 2-9578;Tribenzagan Hydrochloride
储存和溶解度
DMSO:100 mg/mL (235.34 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years