您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > CyPPA
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
CyPPA
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CyPPA图片
CAS NO:73029-73-9
包装与价格:
包装价格(元)
2 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
200 mg电议
500 mg电议
1 mL*10 mM(in DMSO)电议

产品介绍
CyPPA 是hSK2和hSK3的阳性调节剂,其EC50值分别为 5.6 μM 和14 μM。它对 hSK1 和 hIK 通道无活性。

产品描述

CyPPA, a subtype-selective positive modulator of SK channels, decreased spontaneous firing rate, increased the duration of the apamin-sensitive afterhyperpolarization.

体外活性

CyPPA, a positive modulator of SK2 and SK3, reduces the activity of dopaminergic neurons and inhibits dopamine release with EC50 values of 14 μM and 5.6 μM, repectively. CyPPA counteracts hyperdopaminergic behaviors induced by methylphenidate.

体内活性

In vivo studies revealed that systemic administration of CyPPA attenuated methylphenidate-induced hyperactivity and stereotypic behaviors in mice. CyPPA induces a concentration-dependent increase in the apparent Ca2+ sensitivity of channel activation, changing the EC50 (Ca2+) from 429 nM to 59 nM

Cas No.

73029-73-9

分子式

C16H23N5

分子量

285.4

储存和溶解度

DMSO:99 mg/mL (346.89 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years