Cyclothiazide 是AMPA受体的正变构调节剂，可快速抑制 AMPA 受体脱敏，并缓慢增强 AMPA 电流。它可以阻断天然和异源表达的AMPA受体脱敏。

Cyclothiazide is a benzothiadiazide that acts as a potentiator of AMPA receptorsthat potently inhibits AMPA receptor desensitization, positively modulating its response to glutamic acid (EC50 = 3.8 M).

2259-96-3

C14H16ClN3O4S2

389.87

Ethanol:25mM
DMSO:100 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years