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NS11394
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
NS11394图片
CAS NO:951650-22-9
包装与价格:
包装价格(元)
2 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
200 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
NS 11394
产品介绍
NS11394 是可口服GABAA的阳性变构调节剂 (PAM),Ki值为 0.5 nM。它对GABAA的选择性依次为 α5、α3、α2 和α1 受体,具有抗炎和抗焦虑活性。

产品描述

NS11394 is a effective and subtype-selective GABA(A) receptor-positive modulator; possesses a functional efficacy selectivity profile of α(5) >α(3) >α(2) >α(1) at GABA(A) alpha subunit-containing receptors.

激酶实验

Inhibition of FLT3 autophosphorylation: To measure inhibition of FLT3 autophosphorylation, MV4-11 or RS4;11 cells are cultured in low serum media (0.5% FBS) overnight and seeded at a density of 400 000 cells per well in a 96-well plate the following day. The cells are incubated with different concentrations of AC220 for 2 hours at 37 °C. To induce FLT3 autophosphorylation in RS4;11 cells, 100 ng/mL FLT3 ligand is added for 15 minutes after the 2-hour AC220 incubation. Cell lysates are prepared and incubated in 96-well plates precoated with a total FLT3 capture antibody. The coated plates are incubated with either a biotinylated antibody against FLT3 to detect total FLT3 or an antibody against phosphotyrosines to detect FLT3 autophosphorylation. In both cases, a SULFO-tagged streptavidin secondary antibody is used for electrochemiluminescence detection on the Meso Scale Discovery platform. The concentration of AC220 that inhibits FLT3-ITD or TLT3-WT autophosphorylation by 50% represents IC50 value

Cas No.

951650-22-9

分子式

C23H19N3O

分子量

353.425

别名

NS 11394

储存和溶解度

DMSO:43 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years