Progabide 是一种 γ-氨基丁酸 (GABA) 受体激动剂。

Progabide is an agonist of the gamma-aminobutyric acid receptor.

Progabide ( 50, 100 and 200 mg/kg) given IP to male Wistar rats enhance the plasma corticosterone levels by 244, 365, and 476% respectively (t=6.44 to12.55, p<0.01). Progabide (10 mg/kg) fails to change the concentration of corticosterone in plasma (t=0.76, N.S.). The increased plasma corticosterone level induced by administration of 200 mg/kg Progabide is evident 30 (t=2.625, p<0.05), 60 (t=13.13, p<0.001) and 120 min (t=4.07, p<0.01) after drug injection, but returns to the control value 240 min after drug injection (t=0.86, N.S.). Compare with the corresponding control, The greatest corticosterone rise is reached 60 min following the administration of Progabide[1].

62666-20-0

C17H16ClFN2O2

334.77

Gabren;SL 76002;Halogabide;Gabrene

DMSO:225mg/mL (672.1mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years