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Tiagabine
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Tiagabine图片
CAS NO:115103-54-3
包装与价格:
包装价格(元)
10 mg电议
25 mg电议
100 mg电议
200 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
噻加宾
NO328
TGB
Gabitril
NO050328
产品介绍
Tiagabine 是具有抗惊厥特性的选择性GABA 再摄取抑制剂,在突触体、神经元和神经胶质中,能够抑制 [3H]GABA 的重摄取,IC50值分别为 67、446 和 182 nM。

产品描述

Tiagabine is an Anti-epileptic Agent. The physiologic effect of tiagabine is by means of Decreased Central Nervous System Disorganized Electrical Activity.

体外活性

Tiagabine is a potent inhibitor of GABA uptake into neurons and glial cells. It is involved in modulating GABA levels, especially in areas such as the hippocampus and thalamus[2]. Tiagabine not only affected the decay kinetics of the IPSCs, it also reduced the frequency of occurrence of both spontaneous and miniature IPSCs[1].

体内活性

Tiagabine offers a significant neuroprotection in global ischemia in gerbils when given 30 min before ischemia but not when given 3 h after ischemia[3].

Cas No.

115103-54-3

分子式

C20H25NO2S2

分子量

375.55

别名

噻加宾;NO328;TGB;Gabitril;NO050328

储存和溶解度

DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years