Guvacine hydrochloride 是从槟榔中得到的一种生物碱，是GABA摄取抑制剂，IC50为 10 μM。它对几种克隆的 GABA 转运体具有适度的选择性。

Guvacine hydrochloride is an inhibits of GABA uptake (IC50 : 10 μM)

In vivo, guvacine, at doses ranging from 50-100 mg/kg, decreases spontaneous activity in mice.?Administration of guvacine also decreases tail flick reaction time in a rat model of morphine analgesia[1].

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C6H10ClNO2

163.6

DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years