Naloxone HCl Dihydrate 是一种阿片类反向激动剂药物,用于对抗阿片类药物过量的影响。
产品描述
Naloxone HCl Dihydrate is an opioid inverse agonist drug used to counter the effects of opiate overdose.
体外活性
The Ki values of (?)-naloxone for the MOR, KOR, and DOR are 0.559 nM, 4.91 nM, and 36.5 nM, respectively. Naloxone HCl Dihydrate binds to the MOR with approximately 9-fold greater affinity relative to the KOR and around 60-fold greater affinity relative to the DOR.[1]
体内活性
The combination of Naloxone HCl Dihydrate (0.5 mg/kg, i.p.) with tramadol (22 mg/kg) decreases the antiallodynic effect of tramadol. [2]
Cas No.
51481-60-8
分子式
C19H26ClNO6
分子量
399.87
别名
Naloxone hydrochloride dihydrate;二水合盐酸纳洛酮
储存和溶解度
Ethanol:<1 mgml
H2O:16 mg/mL (40 mM)
DMSO:73 mg/mL (182.6 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years