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Naloxone HCl Dihydrate
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Naloxone HCl Dihydrate图片
CAS NO:51481-60-8
包装与价格:
包装价格(元)
25 mg电议
50 mg电议
100 mg电议
200 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
Naloxone hydrochloride dihydrate
二水合盐酸纳洛酮
产品介绍
Naloxone HCl Dihydrate 是一种阿片类反向激动剂药物,用于对抗阿片类药物过量的影响。

产品描述

Naloxone HCl Dihydrate is an opioid inverse agonist drug used to counter the effects of opiate overdose.

体外活性

The Ki values of (?)-naloxone for the MOR, KOR, and DOR are 0.559 nM, 4.91 nM, and 36.5 nM, respectively. Naloxone HCl Dihydrate binds to the MOR with approximately 9-fold greater affinity relative to the KOR and around 60-fold greater affinity relative to the DOR.[1]

体内活性

The combination of Naloxone HCl Dihydrate (0.5 mg/kg, i.p.) with tramadol (22 mg/kg) decreases the antiallodynic effect of tramadol. [2]

Cas No.

51481-60-8

分子式

C19H26ClNO6

分子量

399.87

别名

Naloxone hydrochloride dihydrate;二水合盐酸纳洛酮

储存和溶解度

Ethanol:<1 mgml
H2O:16 mg/mL (40 mM)
DMSO:73 mg/mL (182.6 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years