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Spinorphin
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Spinorphin图片
CAS NO:137201-62-8
包装与价格:
包装价格(元)
1 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
200 mg电议

产品介绍
Spinorphin 是一种脑非肽降解酶抑制剂,能够抑制氨基肽酶、二肽基氨基肽酶III、血管紧张素转换酶和脑非肽酶。它可用于研究疼痛的缓解。

产品描述

Spinorphin is a heptapeptide, and is a potent enkephalin-degrading enzymes inhibitor.

体外活性

Spinorphin inhibited cytoplasmic Ca(2+) ([Ca(2+)]i) transients, evoked by depolarization and capsaicin selectively in medium and small cultured rat DRG neurons.?Spinorphin (10-300 M) inhibited the Ca(2+) signals in concentration dependant manner in small- and medium diameter DRG neurons.?Capsaicin produced [Ca(2+)]i responses only in small- and medium-sized DRG neurons, and pre-treatment with spinorphin significantly attenuated these [Ca(2+)]i responses[1].

体内活性

Spinorphin significantly inhibited the functions of polymorphonuclear neutrophils (PMNs) by suppressing the binding of fMLF to its receptor on PMNs. Further, this inhibitor suppressed the carrageenan-induced accumulation of PMN in mouse air pouches after intravenous administration. These results indicate that spinorphin may be an endogenous anti-inflammatory regulator. The possible role of spinorphin and its analog as regulators in pain and inflammation will be discussed[2].

Cas No.

137201-62-8

分子式

C45H64N8O10

分子量

877.053

储存和溶解度

DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years